Catalytic inhibitors of DNA topoisomerase II
Identifieur interne : 002773 ( Main/Exploration ); précédent : 002772; suivant : 002774Catalytic inhibitors of DNA topoisomerase II
Auteurs : Toshiwo Andoh [Japon] ; Ryoji Ishida [Japon]Source :
- BBA - Gene Structure and Expression [ 0167-4781 ] ; 1998.
English descriptors
- Teeft :
- Aclarubicin, Acta, Adriamycin, Andoh, Anthracycline, Anthracycline antibiotics, Antitumor, Antitumor activity, Bbaexp, Biochem, Biochimica, Biol, Biophysica, Biophysica acta, Bisdioxopiperazine, Bisdioxopiperazines, Cancer chemother, Catalytic, Catalytic cycle, Catalytic inhibitor, Catalytic inhibitors, Catenated, Catenated dimers, Cell biol, Cell cycle, Cell lines, Cell lung cancer cells, Checkpoint, Chemother, Chemotherapy, Chromatid, Chromatin, Chromosome, Chromosome condensation, Chromosome segregation, Cleavable, Cytotoxicity, Daughter molecules, Daunorubicin, Derivative, Dioxopiperazine, Dioxopiperazine compounds, Doxorubicin, Enzyme, Etoposide, Eukaryote, Hamster, Hellmann, Icrf, Icrf compounds, Inhibitor, Ishida, Ishida biochimica, Jensen, Lymphoma, Mammalian cells, Merbarone, Minor groove binding agents, Mitosis, Mitotic, Mutant, Mutation, Narita, Pharmacol, Replication, Saccharomyces cerevisiae, Schedule dependence, Sehested, Simian virus, Similar observations, Topoisomerase, Topoisomerases, Toxicity, Treatment schedule, Wang.
Abstract
Abstract: Catalytic inhibitors of mammalian DNA topoisomerase II have been found recently in natural and synthetic compounds. These compounds target the enzyme within the cell and inhibit various genetic processes involving the enzyme, such as DNA replication and chromosome dynamics, and thus proved to be good probes for the functional analyses of the enzyme in a variety of eukaryotes from yeast to mammals. Catalytic inhibitors were shown to be antagonists against topoisomerase II poisons. Thus bis(2,6-dioxopiperazines) have a potential to overcome cardiac toxicity caused by potent antitumor anthracycline antibiotics such as doxorubicin and daunorubicin. ICRF-187, a (+)-enantiomer of racemic ICRF-159, has been used in clinics in European countries as cardioprotector. Furthermore, bis(2,6-dioxopiperazines) enhance the efficacy of topoisomerase II poisons by reducing their side effects in preclinical and clinical settings. Bis(2,6-dioxopiperazines) per se among others have antitumor activity, and one of their derivatives, MST-16 or Sobuzoxane, bis(N1-isobutyloxycarbonyloxymethyl-2,6-dioxopiperazine), has been developed in Japan as an anticancer drug used for malignant lymphomas and adult T-cell leukemia in clinics.
Url:
DOI: 10.1016/S0167-4781(98)00133-X
Affiliations:
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Le document en format XML
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Gene Structure and Expression</title><title level="j" type="abbrev">BBAEXP</title><idno type="ISSN">0167-4781</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1998">1998</date><biblScope unit="volume">1400</biblScope><biblScope unit="issue">1–3</biblScope><biblScope unit="page" from="155">155</biblScope><biblScope unit="page" to="171">171</biblScope></imprint><idno type="ISSN">0167-4781</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0167-4781</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Aclarubicin</term><term>Acta</term><term>Adriamycin</term><term>Andoh</term><term>Anthracycline</term><term>Anthracycline antibiotics</term><term>Antitumor</term><term>Antitumor activity</term><term>Bbaexp</term><term>Biochem</term><term>Biochimica</term><term>Biol</term><term>Biophysica</term><term>Biophysica acta</term><term>Bisdioxopiperazine</term><term>Bisdioxopiperazines</term><term>Cancer chemother</term><term>Catalytic</term><term>Catalytic cycle</term><term>Catalytic inhibitor</term><term>Catalytic inhibitors</term><term>Catenated</term><term>Catenated dimers</term><term>Cell biol</term><term>Cell cycle</term><term>Cell lines</term><term>Cell lung cancer cells</term><term>Checkpoint</term><term>Chemother</term><term>Chemotherapy</term><term>Chromatid</term><term>Chromatin</term><term>Chromosome</term><term>Chromosome condensation</term><term>Chromosome segregation</term><term>Cleavable</term><term>Cytotoxicity</term><term>Daughter molecules</term><term>Daunorubicin</term><term>Derivative</term><term>Dioxopiperazine</term><term>Dioxopiperazine compounds</term><term>Doxorubicin</term><term>Enzyme</term><term>Etoposide</term><term>Eukaryote</term><term>Hamster</term><term>Hellmann</term><term>Icrf</term><term>Icrf compounds</term><term>Inhibitor</term><term>Ishida</term><term>Ishida biochimica</term><term>Jensen</term><term>Lymphoma</term><term>Mammalian cells</term><term>Merbarone</term><term>Minor groove binding agents</term><term>Mitosis</term><term>Mitotic</term><term>Mutant</term><term>Mutation</term><term>Narita</term><term>Pharmacol</term><term>Replication</term><term>Saccharomyces cerevisiae</term><term>Schedule dependence</term><term>Sehested</term><term>Simian virus</term><term>Similar observations</term><term>Topoisomerase</term><term>Topoisomerases</term><term>Toxicity</term><term>Treatment schedule</term><term>Wang</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Catalytic inhibitors of mammalian DNA topoisomerase II have been found recently in natural and synthetic compounds. These compounds target the enzyme within the cell and inhibit various genetic processes involving the enzyme, such as DNA replication and chromosome dynamics, and thus proved to be good probes for the functional analyses of the enzyme in a variety of eukaryotes from yeast to mammals. Catalytic inhibitors were shown to be antagonists against topoisomerase II poisons. Thus bis(2,6-dioxopiperazines) have a potential to overcome cardiac toxicity caused by potent antitumor anthracycline antibiotics such as doxorubicin and daunorubicin. ICRF-187, a (+)-enantiomer of racemic ICRF-159, has been used in clinics in European countries as cardioprotector. Furthermore, bis(2,6-dioxopiperazines) enhance the efficacy of topoisomerase II poisons by reducing their side effects in preclinical and clinical settings. Bis(2,6-dioxopiperazines) per se among others have antitumor activity, and one of their derivatives, MST-16 or Sobuzoxane, bis(N1-isobutyloxycarbonyloxymethyl-2,6-dioxopiperazine), has been developed in Japan as an anticancer drug used for malignant lymphomas and adult T-cell leukemia in clinics.</div></front></TEI><affiliations><list><country><li>Japon</li></country><region><li>Région de Kantō</li></region><settlement><li>Tokyo</li></settlement></list><tree><country name="Japon"><region name="Région de Kantō"><name sortKey="Andoh, Toshiwo" sort="Andoh, Toshiwo" uniqKey="Andoh T" first="Toshiwo" last="Andoh">Toshiwo Andoh</name></region><name sortKey="Andoh, Toshiwo" sort="Andoh, Toshiwo" uniqKey="Andoh T" first="Toshiwo" last="Andoh">Toshiwo Andoh</name><name sortKey="Ishida, Ryoji" sort="Ishida, Ryoji" uniqKey="Ishida R" first="Ryoji" last="Ishida">Ryoji Ishida</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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